Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. Overdosage may result in electrolyte disturbances including hypokalemia, hypocalcemia, and hypomagnesemia. Monitor serum potassium during therapy because severe hypokalemia may occur. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The practical exchange ratio is 1 mEq K per 1 gram of resin. This medicine may be used for other purposes; ask your health care provider or … The dose of this medicine will be different for different patients. Adjustment of other sources of sodium may be required. Do not use two doses at one time. Sodium polystyrene sulfonate may also be used for purposes not listed in this medication guide. Avoid taking other medicines within 3 hours before or 3 hours after you take sodium polystyrene sulfonate. Concomitant administration of sorbitol is not recommended. Version: 4.02. sodium bicarbonate, Kayexalate, insulin regular, calcium gluconate, Humulin R, Veltassa. Too much potassium in your blood can sometimes cause heart rhythm problems. This medication is used to treat a high level of potassium in your blood. Sodium Polystyrene Sulfonate is not totally selective for potassium, and small amounts of other cations such as magnesium and calcium can also be lost during treatment. Administer Sodium Polystyrene Sulfonate with the patient in an upright position. Sodium Polystyrene Sulfonate is a non-absorbed, cation exchange polymer that contains a sodium counterion. Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Uses; Before taking; Warnings; Dosage; Side effects; Storage; Uses of Sodium Polystyrene Sulfonate Powder: Don't delay your care at Mayo Clinic. Sodium polystyrene sulfonate works differently from other medicines because it passes into your intestines without being absorbed into your blood stream. You may report side effects to FDA at 1-800-FDA-1088. Hypersensitivity to polystyrene sulfonate resins, The drug is a cream to light brown finely ground, powdered form of Sodium Polystyrene Sulfonate, a cation-exchange resin prepared in the sodium phase with an, Store at 25° C (77° F); excursions permitted to 15° – 30° C (59° – 86° F), Sodium Polystyrene Sulfonate powder, for suspension, We comply with the HONcode standard for trustworthy health information -. The intensity and duration of therapy depend upon the severity and resistance of hyperkalemia. Sodium Polystyrene Sulfonate (By mouth) SOE-dee-um pol-ee-STYE-reen SUL-foe-nate. Sodium polystyrene sulfonate binds to many commonly prescribed oral medicines, decreasing the absorption and therefore the effectiveness of those oral medicines. It works by removing excess potassium from the body. Sodium polystyrene sulfonate can be given as a liquid by mouth, through a stomach feeding tube, or as a rectal enema. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Oral. The following adverse reactions are discussed elsewhere in the labeling: The following adverse reactions have been identified during post-approval use of Sodium Polystyrene Sulfonate. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or establish a causal relationship to drug exposure. Effects generally take hours to days. Administer other oral medications at least 3 hours before or 3 hours after Sodium Polystyrene Sulfonate. Last updated on Dec 1, 2019. Sodium Polystyrene Sulfonate is indicated for the treatment of hyperkalemia. Avoid use in patients who are at risk for developing constipation or impaction (including those with history of impaction, chronic constipation, inflammatory bowel disease, ischemic colitis, vascular intestinal atherosclerosis, previous bowel resection, or bowel obstruction). Do not heat Sodium Polystyrene Sulfonate as it could alter the exchange properties of the resin. Follow all directions on your prescription label and read all medication guides or instruction sheets. The report evaluates the opportunities and current market scenario, providing insights and updates about the … Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Binding of Sodium Polystyrene Sulfonate to other oral medications could cause decreased gastrointestinal absorption and loss of efficacy when taken close to the time Sodium Polystyrene Sulfonate is administered. Limitation of Use: Sodium Polystyrene Sulfonate should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action [see Clinical Pharmacology (12.2)]. Avoid taking other medicines by mouth within 3 hours before or 3 hours after you take sodium polystyrene sulfonate (or 6 hours before/after if you have slow digestion). Appropriate measures should be taken to correct serum electrolytes (potassium, calcium, magnesium), and the resin should be removed from the alimentary tract by appropriate use of laxatives or enemas. KAYEXALATE is a cation-exchange resin prepared in the sodium phase, with an in vivo exchange capacity of approximately 1 mmol (in vitro approximately 3.1 mmol) of potassium per gram. The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an in vitro exchange capacity of approximately 3.1 mEq (in vivo approximately 1 mEq) of potassium per gram.The sodium content is approximately 100 mg (4.1 mEq) per gram of the drug. Store at 25° C (77° F); excursions permitted to 15° – 30° C (59° – 86° F) [see USP Controlled Room Temperature]. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. The amount of medicine that you take depends on the strength of the medicine. Sodium Polystyrene Sulfonate is a potassium ion exchange resin composed of benzene -diethyl polymer with ethenyl-benzene, sulfonated, sodium salt. Before Using It is used to treat too much potassium in the body. They are also used to remove potassium, calcium, and sodium from solutions in technical applications. Sodium polystyrene sulfonate binds itself to potassium in your digestive tract. Risk factors for gastrointestinal adverse events were present in many of the cases including prematurity, history of intestinal disease or surgery, hypovolemia, and renal insufficiency and failure. Avoid eating or drinking anything that contains sorbitol (a fruit sugar often used as a sweetener in chewing gum, diet drinks, baked goods, or frozen desserts). After an initial cleansing enema, insert a soft, large size (French 28) rubber tube into the rectum for a distance of about 20 cm, with the tip well into the sigmoid colon, and tape in place. Oral:15 g orally once a dayMaximum dose: 15 g orally 4 times a dayComments:-A 15 g dose is equivalent to approximately 4 level teaspoons.-This drug should be given as a suspension in water or syrup (not fruit juice).Rectal:30 g rectally every 6 hoursMaximum dose: 50 g rectally every 6 hoursComments:-This drug should be administered via warm emulsion in 100 mL of aqueous vehicle.-This solution should be gently agitated during administration.-The enema should be retained as long as possible and should be followed by a cleansing enema.Use: Treatment of hyperkalemia, Calculate dose based on 1 mEq potassium per 1 g resinComment:-A 15 g dose is equivalent to approximately 4 level teaspoons.-This drug should be given as a suspension in water or syrup (not fruit juice).-The oral route should be avoided in neonates.Use: Treatment of hyperkalemia. The in vivo efficiency of sodium-potassium exchange resins is approximately 33 percent; hence, about one third of the resin's actual sodium content is delivered to the body. Limitation of Use: Sodium Polystyrene Sulfonate should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action [see Clinical Pharmacology (12.2)]. Monitor for clinical response and/or blood levels where possible. in vitro. If you have a condition that slows your digestion, avoid taking other medicines by mouth within 6 hours before or 6 hours after you take sodium polystyrene sulfonate. Administer as a warm (body temperature) emulsion in 100 mL of aqueous vehicle and flush with 50 to 100 ml of fluid. Sodium Polystyrene Sulfonate is not absorbed systemically by the mother, so breastfeeding is not expected to result in risk to the infant. The simultaneous oral administration of Sodium Polystyrene Sulfonate with nonabsorbable cation- donating antacids and laxatives may reduce the resin's potassium exchange capability and increase the risk of systemic alkalosis. Do not give sodium polystyrene sulfonate orally (by mouth) to a newborn baby. If necessary, sodium polystyrene sulfonate may be administered into the stomach through a plastic tube. pressure when sodium intake is not restricted, pre-sumably by promoting renal sodium retention. Last updated on Oct 23, 2020. Sorbitol may contribute to the risk of intestinal necrosis [see Warnings and Precautions (5.1)] and concomitant use is not recommended. The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an exchange capacity of approximately 3.1 mEq (approximately 1 mEq) of potassium per gram. KAYEXALATE, brand of sodium polystyrene sulfonate is a benzene, diethenyl-polymer, with ethenylbenzene, sulfonated, sodium salt and has the following structural formula: The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an . Generic Name: Sodium Polystyrene Sulfonate Powder (SOE dee um POL ee STYE reen SUL foe nate) Brand Name: Kayexalate, Kionex. Administer Sodium Polystyrene Sulfonate at least 3 hours before or 3 hours after other oral medications. Some drugs may have to be approved before the plan covers them. If your dose is different, do not change it unless your doctor tells you to do so. This helps prevent your body from absorbing too much potassium. Sodium polystyrene sulfonate is used to treat hyperkalemia (increased amounts of potassium in the body). One level teaspoon contains approximately 3.5 g of Sodium Polystyrene Sulfonate and 15 mEq of sodium. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. No formal drug interaction studies have been conducted in humans. The average total daily adult dose of Sodium Polystyrene Sulfonate is 15 g to 60 g, administered as a 15-g dose (four level teaspoons), one to four times daily. Gastrointestinal: anorexia, constipation, diarrhea, fecal impaction, gastrointestinal concretions (bezoars), ischemic colitis, nausea, ulcerations, vomiting, gastric irritation, intestinal obstruction (due to concentration of aluminium hydroxide). The majority of these cases reported the concomitant use of sorbitol. Sodium Polystyrene Sulfonate is contraindicated in patients with the following conditions: Cases of intestinal necrosis, some fatal, and other serious gastrointestinal adverse events (bleeding, ischemic colitis, perforation) have been reported in association with Sodium Polystyrene Sulfonate use. Decreased absorption of lithium and thyroxine have also been reported with co-administration of Sodium Polystyrene Sulfonate. Cases of acute bronchitis or bronchopneumonia caused by inhalation of Sodium Polystyrene Sulfonate particles have been reported. Sodium Polystyrene Sulfonate is available as a cream to light brown, finely ground powder in jars of 1 pound (453.6 g), NDC 50488-5001-1. Sodium Polystyrene Sulfonate is indicated for the treatment of hyperkalemia. Stop using sodium polystyrene sulfonate and call your doctor at once if you have: severe constipation, severe stomach pain, bloating; confusion, thinking problems, feeling irritable; low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; low calcium levels--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes); or. Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. The client also needs to make some dietary changes. Written by Cerner Multum. Call your doctor for medical advice about side effects. Sodium Polystyrene Sulfonate is indicated for the treatment of hyperkalemia. It can be administered orally or rectally as an enema. Sodium Polystyrene Sulfonate is a benzene, diethenyl-polymer, with ethenylbenzene, sulfonated, sodium salt and has the following structural formula: The drug is a cream to light brown finely ground, powdered form of Sodium Polystyrene Sulfonate, a cation-exchange resin prepared in the sodium phase with an in vitro exchange capacity of approximately 3.1 mEq (in vivo approximately 1 mEq) of potassium per gram. Drug Interactions. Suspend each dose in a small quantity of water or syrup, approximately 3 to 4 mL of liquid per gram of resin. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Patients with gastroparesis may require a 6 hour separation. Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. Polystyrene sulfonates are a group of medications used to treat high blood potassium. Sodium polystyrene sulfonate works differently from other medicines because it … Synonyms SDS Certificate of Analysis Product Specification Technical Inquiry Stock No. Too much potassium in your blood can sometimes cause heart rhythm problems. Quasi-elastic light-scattering spectroscopy was used to measure the diffusion coefficient of polystyrene latex spheres of diameters 14, 67, and 189 nm in relatively dilute (concentrations 0 ≤ c ≤ 20 g/L) solutions of polystyrene sulfonate. This is not a complete list of side effects and others may occur. It is used to treat too much potassium in the body. Applies to sodium polystyrene sulfonate: oral or rectal powder for suspension, oral or rectal suspension Side effects include: Gastric irritation, anorexia, constipation, diarrhea, fecal impaction, GI concretions (bezoars), nausea, vomiting, hypokalemia, hypocalcemia, hypomagnesemia, clinically important sodium retention. Medically reviewed by Drugs.com. Other drugs may affect sodium polystyrene sulfonate, including prescription and over-the-counter medicines, vitamins, and herbal products. KAYEXALATE (sodium polystyrene sulfonate) is a cream or light brown fine powder of sodium polystyrene sulfonate. Sodium polystyrene sulfonate is in a class of medications called potassium-removing agents. Monitor patients who are sensitive to sodium intake (heart failure, hypertension, edema) for signs of fluid overload. In some Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. The resin should be retained for as long as possible and follow by a cleansing enema with a nonsodium containing solution. In pediatric patients, as in adults, Sodium Polystyrene Sulfonate is expected to bind potassium at the practical exchange ratio of 1mEq potassium per 1 gram of resin. Which foods should the client avoid? Average adult dose: 15 g (approximately 4 level Teaspoons) one to four times daily in water. Sodium polystyrene sulfonate can make it harder for your body to absorb medicines you take by mouth. Polymer molecular weights were in the range 1.5 ≤ M ≤ 1188 kDa; solvents were in the high-salt (0.2M NaCl) regime. The sodium content is approximately 100 mg (4.1 mEq) per gram of the drug. 70,000 . A low serum potassi-um concentration indicates disruption of normal homeostasis, with one very rare exception. This medication is used to treat a high level of potassium in your blood. Commercially Available Suspension Shake the suspension well before administering. In neonates, Sodium Polystyrene Sulfonate should not be given by the oral route. Sodium polystyrene sulfonate, USP is a cream to light brown, finely ground powder and is available in 454 g jars and 15 g bottles. Treats hyperkalemia (high levels of potassium in the blood). Prepare suspension fresh and use within 24 hours. Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. Administer Sodium Polystyrene Sulfonate at least 3 hours before or 3 hours after other oral medications. Sodium Polystyrene Sulfonate may bind orally administered medications, which could decrease their gastrointestinal absorption and lead to reduced efficacy. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem f… Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Patients with gastroparesis may require a 6 hour separation [see Warnings and Precautions (5.5) and Drug Interaction (7)]. 16 Hypokalemia is rarely suspected on the basis of clinical presentation; the diagnosis is made by meas-urement of serum potassium. Store at room temperature away from moisture and heat. Monitor calcium and magnesium in patients receiving Sodium Polystyrene Sulfonate. Sodium polystyrene sulfonate works differently from other medicines because it passes into your intestines without being absorbed into your blood stream. Some may affect sodium polystyrene sulfonate, especially: drugs that weaken the immune system such as cancer medicine, steroids, and medicines to prevent organ transplant rejection. Ensure an adequate volume of cleansing solution (up to 2 liters) is utilized. For non-prescription products, read the label or package ingredients carefully. exchange In in vitro binding studies, Sodium Polystyrene Sulfonate was shown to significantly bind the oral medications (n=6) that were tested. You will need frequent medical tests to help your doctor determine how long to treat you with sodium polystyrene sulfonate. 25704-18-1. To give this medicine orally: Mix the sodium polystyrene sulfonate powder with water, or with honey or jam to make it taste better. Cabbage Mushrooms Strawberries. The effect must be carefully controlled by frequent serum potassium determinations within each 24 hour period. Advise patients who are taking other oral medication to separate the dosing of Sodium Polystyrene Sulfonate by at least 3 hours (before or after) [see Dosage and Administration (2.1), Warnings and Precautions (5.5), and Drug Interactions (7.1)]. A client has a prescription to take sodium polystyrene sulfonate for several days. Exchange Resin (About this - PubMed Health) Uses Uses of This Medicine Medically reviewed by Drugs.com. Premature infants or low birth weight infants may have an increased risk for gastrointestinal adverse effects with Sodium Polystyrene Sulfonate use [see Warnings and Precautions (5.4)]. signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds. The effective lowering of serum potassium with Sodium Polystyrene Sulfonate may take hours to days. In addition to lowering average potassium content by 65%, the calcium content of breastmilk was reduced by 84%. Keep using this medicine even if you feel fine. Hyperkalemia often has no symptoms that you will notice until your potassium levels are very low. You should not use sodium polystyrene sulfonate if you have low potassium levels or a bowel obstruction. Follow your doctor's orders or the directions on the label. In both children and neonates, excessive dosage or inadequate dilution could result in impaction of the resin. Administer with patient in an upright position [see Warnings and Precautions (5.4)]. sodium polystyrene sulfonate) Administration of IV Insulin-Glucose, and inhaled beta-agonists (albuterol) IV Calcium administration to prevent cardiac arrythmias. The sodium content is approximately 100 mg (4.1 mEq) per gram of the drug. Drug classes. This list is not complete. The following information includes only the average doses of this medicine. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. Studies of safety and efficacy have not been conducted in pediatric patients.